Research Interests :

• Neural mechanisms of vocal learning in songbird : role of the basal ganglia (Main project)

• Pathological dynamics of the basal ganglia network in Parkinson’s disease and dystony

• Role of the striatal feedforward inhibition in absence epilepsy

Methods :

• Electrophysiology

• computational modelling

• behavioral analysis

1. Reese R*, Leblois A*, Steigerwald F, Pötter-Nerger M, Herzog J, Mehdorn HM, Deuschl G, Meissner WG, Volkmann J (2011) Subthalamic deep brain stimulation increases pallidal firing rate and regularity. Exp Neurol. 229:517-21

2. Leblois A*, Reese R*, Labarre D, Boraud T, Hamann M, Richter A, Meissner W (2010) Deep brain stimulation changes basal ganglia output nuclei firing pattern in the dystonic hamster. Neurobiol Dis. 38:288-98.

3. Leblois A, Wendel BJ, Perkel DJ (2010) Striatal dopamine modulates basal ganglia output and regulates social context-dependent behavioral variability through D1 receptors. J. Neurosci. 30:5730-43.

4. Leblois A, Bodor AL, Person AL, Perkel DJ (2009) Millisecond timescale disinhibition of thalamic neurons by relief of single spike basal ganglia GABAergic veto. J. Neurosci. 29 : 15420-15433.

5. Leblois A, Meissner W, Bioulac B, Gross C, Hansel D, Boraud T (2007) Late emergence of synchronized oscillatory activity in the pallidum during progressive parkinsonism. Eur. J. Neurosci. 26 : 1701–1713.

6. Leblois A, Meissner W, Bezard E, Bioulac B, Gross C, Boraud T (2006) The time dimension in GPi neuronal encoding : a key to parkinsonian motor slowness ? Eur. J. Neurosci. 24 : 1201–1208.

7. Leblois A, Boraud T, Meissner W, Bergman H, Hansel D (2006) Competition between feedback loops underlie normal and pathological dynamics in the basal-ganglia. J. Neurosci. 26 : 3567-83.

8. Leblois A, Boraud T, Meissner W, Bergman H, Hansel D. (2006) “Competition between feedback loops as the core of a computational model of the basal ganglia.” Book chapter in : “Recent Breakthrough in Basal Ganglia Research”, E. Bezard (ed), New York : Nova.

9. Meissner W, Leblois A, Hansel D, Bioulac B, Gross C, Benazzouz A, Boraud T (2005) Subthalamic high frequency stimulation resets subthalamic firing and reduces abnormal oscillations. Brain 128 : 2372-2382.

Contact Information :

Laboratory of Neurophysics and Physiology - CNRS UMR 8119
Paris Descartes University
45 Rue des Saints Pères
75006 Paris
France

Tel : +33 (0) 1 42 86 22 72
Fax : +33 (0) 1 49 27 90 62

Email : arthur.leblois parisdescartes.fr

Biomedical unit - 1950